Yeguang CHEN Ph.D.
Professor Academician of the Chinese Academy of Sciences
1979-1983 Jiangxi University, BSc of Biology
1983-1986 Jiangxi University, MSc of Zoology
1988-1990 Fordham University，MSc of Cell Biology
1991-1996 Albert Einstein College of Medicine，PhD of Cell Biology
1996-2000 Post-doctoral Research Associate, Memorial Sloan-Kettering Cancer Center/Howard Hughes Medical Institute
2000-2002 Assistant Professor, University of California, Riverside
2002-present Professor, School of Life Sciences, Tsinghua University
Research interest
The lab mainly focus on the molecular mechanisms of TGF-β signaling and Wnt signaling in regulating cell fates and related physiological and pathological functions; Using multiple techniques of molecular biology, cell biology and bioinformatics in combination with organoid culture and mouse models, we also investigate the self-renewal and differentiation mechanisms of adult stem cells of intestine and stomach, and explore the pathogenic mechanisms of related diseases.
Courses offered
Cell Biology; Topics in Tumor Biology
Selected publications
1. Nong J, Kang K, Shi Q, Zhu X, Tao Q, Chen YG#. 2021 Phase separation of Axin organizes the β-catenin destruction complex. Journal of Cell Biology, 220(4):e202012112.
2. Wang YL, Song WL, Wang JL, Wang T, Xiong XC, Qi Z, Fu W#, Yang XR#, Chen YG#. 2020 Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine. Journal of Experimental Medicine, 217(2):e20191130.
3. Li Y, Liu Y, Chiang YJ, Huang F, Li Y, Li X, Ning Y, Zhang W, Deng H, Chen YG#. 2019 DNA damage activates TGF-β signaling via ATM-c-Cbl-mediated stabilization of the type II receptor TβRII. Cell Reports, 28(3):735-745.e4.
4. Huang F, Shi Q, Li Y, Xu L, Xu C, Chen F, Wang H, Liao H, Chang Z, Liu F, Zhang XH, Feng XH, Han JJ, Luo S, Chen YG#. 2018 HER2/EGFR-AKT signaling switches TGF-β from inhibiting cell proliferation to promoting cell migration in breast cancer. Cancer Research, 78(21):6073-6085.
5. Qi Z, Li Y, Zhao B, Xu C, Liu Y, Wang X, Yang X, Li B, Han JD, Chen YG#. 2017 BMP restricts the self-renewal of intestinal Lgr5+ stem cells by directly suppressing their signature genes. Nature Communications, 8:13824.
6. Zhao B, Qi Z, Li Y, Wang C, Fu W, Chen YG# 2015 The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells. Nature Communications, 6:7166.
7. Zuo W, Huang F, Chiang YJ, Li M, Du J, Ding Y, Zhang T, Lee HW, Jeong LS, Chen Y, Deng H, Feng XH, Luo S, Gao C, Chen YG# 2013 c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor. Molecular Cell, 49(3):499-510.
8. Li Z, Fei T, Zhang J, Zhu G, Wang L, Lu D, Chi X, Teng Y, Hou N, Yang X, Zhang H, Han JD, Chen YG# 2012 BMP4 signaling acts via Dual Specificity Phosphatase 9 to control ERK activity in mouse embryonic stem cells. Cell Stem Cell, 10:171-182.
9. Gao C, Cao W, Bao W, Zuo W, Xie G, Cai T, Fu W, Zhang J, Wu W, Zhang X, Chen YG# 2010 Autophagy negatively regulates Wnt signaling by promoting Dishevelled degradation. Nature Cell Biology, 12:781-790.
10. Zhang W, Jiang Y, Wang Q, Ma X, Xiao Z, Zuo W, Fang X#, Chen YG# 2009 Single molecule imaging reveals transforming growth factor-β-induced type II receptor dimerization. Proc Natl Acad Sci. USA, 106:15679-15683.
11. Wang Q, Huang Z, Xue H, Jin C, Ju XL, Han JD, Chen YG# 2008 MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4. Blood, 111:588-595.
12. Zhang L, Zhou H, Su Y, Sun S, Zhang H, Zhang L, Zhang Y, Ning Y, Chen YG#, Meng A# 2004 Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of Nodal receptors. Science, 306:114-117.
Contact information
Tel：010-62784794；
E-mail：ygchen@mail.tsinghua.edu.cn
Websites: http://ygc.life.tsinghua.edu.cn
